Pharmalot Top of the morning to you, and a fine one it is. We may have returned from a sojourn abroad, but we are enjoying another busy day, thanks to the first ever #STATSummit taking place today in Cambridge (Massachusetts, not England). All sorts of interesting people and topics are on hand, so take a peek if you are unable to join us. Of course, we also look forward to the cups of stimulation being served. Meanwhile, we are pleased to provide the latest menu of tidbits. Have a smashing day and do keep in touch.President Trump and senators from both parties are still hoping to force drug makers to disclose list prices in TV ads, The Hill reports. The disclosure rule was one of Trump’s highest-profile initiatives and the first policy released after the administration unveiled its drug pricing “blueprint” in 2018. But in July, a federal judge sided with a coalition of three drug makers and advertisers and blocked the Trump administration from implementing the policy. By Ed Silverman Nov. 21, 2019 Reprints What is it? Pharmalot Columnist, Senior Writer Ed covers the pharmaceutical industry. What’s included? Alex Hogan/STAT Ed Silverman STAT+ is STAT’s premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond. Tags pharmalittleSTAT+ About the Author Reprints @Pharmalot Pharmalittle: Trump and senators push for drug prices in TV ads; Sanofi looks to spin off consumer business Log In | Learn More Unlock this article by subscribing to STAT+ and enjoy your first 30 days free! GET STARTED Daily reporting and analysis The most comprehensive industry coverage from a powerhouse team of reporters Subscriber-only newsletters Daily newsletters to brief you on the most important industry news of the day STAT+ Conversations Weekly opportunities to engage with our reporters and leading industry experts in live video conversations Exclusive industry events Premium access to subscriber-only networking events around the country The best reporters in the industry The most trusted and well-connected newsroom in the health care industry And much more Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr. GET STARTED [email protected]
Home Iliad earnings boosted by strong mobile additions Tags Iliad overcame “persistently fierce competition” in France to report a strong Q3 performance, bolstered by the addition of 250,000 mobile subscribers, as the company edges closer towards a launch in Italy.The operator, which entered France in 2012 through mobile and internet brand Free, shook up the market by increasing the number of operators from three to four, sparking a period of aggressive promotions to capture, or indeed maintain, market share.Free, in particular, pushed lower prices and attributed this quarter’s subscriber growth largely to its Free Mobile Plan, offering unlimited calls, texts, 25GB of data, and roaming for €19.99 a month.Iliad said Q3 net additions left it close to 13.4 million mobile subscribers in total, and represented the highest number of net adds in France for the 23rd consecutive quarter. The operator ended the period with an 18.7 per cent share of overall French mobile subscribers.The company added one in two of its subscribers now had access to 4G, amounting to 7.4 million 4G subscribers in total, while it also reported a “record-breaking quarter” for FTTH connections, with 64,000 new subscribers, in addition to 27,000 new broadband and ultra-fast broadband subscriber additions.On the back of the strong subscriber gains, Iliad reported a year-on-year revenue rise of 5.3 per cent to €1.24 billion, from €1.18 billion in Q3 2016, with mobile revenue increasing 6.3 per cent to €554 million.Iliad did not provide a Q3 profit figure.Italy launchThe company is now ever closer to a long-awaited launch in Italy, which is expected to happen at the end of 2017 or early 2018.Iliad’s Italian unit, which it acquired as part of a deal which saw CK Hutchison’s Italian unit merge with Veon’s local business, represents the company’s first major move outside of France.The company said earlier this year it plans to adopt an aggressive pricing strategy in Italy, similar to the one deployed in France, in its bid to capture market share.Although there was no mention of Italy in its Q3 results announcement, Iliad CFO Thomas Reynaud told Reuters it was close to finalising its team for launch in Italy.“More than 70 people have already been recruited, essentially in Milan but also in Rome,” he said: “The staff will continue to grow and we’ll be present in several cities, notably to deploy our network.”. Kavit Majithia Google dismisses Italy claims of market position abuse Kavit joined Mobile World Live in May 2015 as Content Editor. He started his journalism career at the Press Association before joining Euromoney’s graduate scheme in April 2010. Read More >> Read more AddThis Sharing ButtonsShare to LinkedInLinkedInLinkedInShare to TwitterTwitterTwitterShare to FacebookFacebookFacebookShare to MoreAddThisMore 16 NOV 2017 Related Serie A, Google give piracy apps the boot Previous ArticleP&G sees huge opportunity in digital disruptionNext ArticleDeutsche Telekom CEO open to going Dutch with Tele2 Author Italy probes CK Hutchison, Cellnex tower deal IliadItalyQ3
AFD and Eskom commit to a competitive electricity sector UNDP China, CCIEE launch report to facilitate low-carbon development Low carbon, solar future could increase jobs in the future – SAPVIA Previous articlePreferred bidders remain hopeful in South AfricaNext articleNigeria: new solar mini grid to electrify 500 homes Babalwa BunganeBabalwa Bungane is the content producer for ESI Africa – Clarion Events Africa. Babalwa has been writing for the publication for over five years. She also contributes to sister publications; Smart Energy International and Power Engineering International. Babalwa is a social media enthusiast. Sustainable world concept. 3D computer generated image. Who will benefit the most from the increasing volume of electrical and electronic scrap worldwide in the future? This question was among many other burning questions, which were addressed at the recent International Electronics Recycling Congress in Austria.The forum discussed all aspects related to E-waste recycling, from current market developments and new technological trends to new legal frameworks and specific country reports.Participating in a round table discussion, Stephan Schwarz from ALBA International Recycling explained that some recycling companies have benefited from substandard recycling activities. Read more…In many cases, E-waste has been shipped to developing countries and dumped, and as a result in this way, large profits were achieved.However, Schwarz believes that the practise of dumping will decrease. The E-waste market has become very dynamic.He noted that products have become increasingly powerful and complex, but also smaller and less valuable. The classic recycling strategy of recovering valuables, mostly metals, will no longer work, the ALBA representative said.Handpicking in developing countries will also no longer produce enough valuable substances.Instead, new recycling technologies and increasingly automated processes are needed.However, Schwarz said it is not only important for the right technology, but also for access to sufficient E-waste volumes.Dynamic E-waste marketAccording to Schwarz, those who can meet both these requirements have a good chance of being among the winners in the E-waste market.Also participating in the discussion, Stuart Fleming, CEO of the E-waste recycler EnviroServe, took a different view of things.Fleming anticipates that the OEM’s will be the winners in the E-waste market.But only on the condition that they are clever enough to take over E-waste recycling companies so that they can harvest the raw materials at reduced rates.In this scenario, he suggests that the OEM will invest some of the extra margin they return into research and development on sustainable practices. Finance and Policy Generation BRICS Featured image: Stock RELATED ARTICLESMORE FROM AUTHOR
Pinellas County Sheriffs Office(PALM HARBOR, Fla.) — Two sisters are accused of killing their 85-year-old father in a chilling, premeditated plot that was uncovered four years later, thanks to a man, who had a sexual relationship with both sisters and came forward, authorities said.Linda Roberts, 61, and Mary-Beth Tomaselli, 63, were arrested and charged with first-degree murder for the 2015 death of their father, Anthony Tomaselli, the Pinellas County Sheriff’s Office said in a statement on Tuesday.“This is in some respects — as we sometimes call these things — it’s the perfect murder, because there was absolutely no sign of struggle, no sign of foul play,” Pinellas County Sheriff Bob Gualtieri told reporters Tuesday. “He had cancer, he had dementia, he was seriously ill … They could have easily gotten away with it.”The alleged crime took place on March 6, 2015, when the sisters were at their father’s Palm Harbor, Fla., home. The sisters called 911 for help and paramedics rushed to the scene and tried to do CPR on Anthony Tomaselli, but he was declared dead, according to the sheriff’s office.At the time “there did not appear to be any foul play or criminal activity,” the sheriff’s office said.Anthony Tomaselli had an “extensive medical history and when contact was made with his primary care physician, he agreed to sign the death certificate,” the sheriff’s office said. “The physician listed the cause of death as natural due to Tomaselli’s advanced age and medical history.”But this year, on Feb. 13, a man, who had a sexual relationship with both sisters, contacted authorities to say he had a recording of Linda Roberts confessing, Gualtieri said.The man then helped authorities obtain recordings from both women about the crime, Gualtieri said.The women allegedly said on the recordings that they first plotted to kill their father with alcohol and sleeping pills, but that didn’t work, and they allegedly tried to suffocate him with a pillow, according to the sheriff’s office.“When that did not work, they stuffed a rag down his throat, pinched his nose, and held his arms down until he stopped breathing and died,” according to the sheriff’s office.Mary-Beth Tomaselli allegedly said her adult daughter was at the home at the time so she gave her sleeping pills so she wouldn’t see what happened to her grandfather, authorities said.The sisters allegedly said they “faked” finding their father dead and staged giving him CPR and calling 911 for help, authorities said.The sisters allegedly said “they ‘euthanized’ their father” in a “premeditated” killing “because he was going to die within a couple months and would not live in an Assisted Living Facility,” the sheriff’s office said.After Anthony Tomaselli’s death, his daughters sold his home and split the money with their brother, who was not involved in the alleged crime, authorities said.The sisters admitted to the allegations when they were arrested Tuesday — a day before their father’s death anniversary, according to the sheriff.The sheriff praised the man, who allegedly recorded the sisters, for coming forward.Roberts and Tomaselli are expected to get arraigned for the charges on Wednesday.Copyright © 2019, ABC Radio. All rights reserved.
Share on Twitter Email Share LinkedIn Aging takes its toll on the brain, and the cells of the hippocampus–a brain region with circuitry crucial to learning and memory–are particularly vulnerable to changes that can lead to Alzheimer’s disease or cognitive decline. With the hope of counteracting the changes that can lead to these two conditions, researchers at Rockefeller University and their colleagues have begun examining the effects of a drug known to affect this circuitry.In new research described recently in Molecular Psychiatry, a team led by Ana Pereira, Instructor in Clinical Medicine in Bruce McEwen’s laboratory found that the drug, riluzole, is capable of reversing key genetic changes associated with these conditions.“In aging and Alzheimer’s, the chemical signal glutamate can accumulate between neurons, damaging the circuitry,” Pereira says. “When we treated rats with riluzole, we saw a suite of changes. Perhaps most significantly, expression of molecules responsible for clearing excess glutamate returned to more youthful levels.” Pinterest Share on Facebook Previous work in McEwen’s lab by Pereira has shown that the drug prompted structural changes in rats’ neurons that prevent the memory loss often seen in old animals. Pereira is currently testing riluzole for the first time in Alzheimer’s patients in a clinical trial at the Rockefeller University Hospital.Glutamate clean upGenerally, glutamate is released to excite other neurons and doesn’t linger in the spaces between them. As we age, though, the system gets a little leaky and glutamate can build up in these intercellular spaces. This happens in part when neurons make less and less of the transporter molecule responsible for removing excess glutamate. When it accumulates, this essential neurotransmitter can cause big problems, damaging or killing neurons and so contributing to Alzheimer’s disease, and other disorders.Pereira and co-first author Jason Gray, a postdoc in the lab sought to better understand the molecular vulnerabilities of an aging glutamate system and riluzole’s effect on it.“The essence is we used a drug known to modulate glutamate, and when we gave it to old rats, we saw it reversed many of the changes that begin in middle age in the hippocampus,” Gray says. “We saw a similar pattern when we compared the riluzole-induced changes to data from Alzheimer’s patients–in a number of key pathways in the hippocampus, the drug produced an effect opposing that of the disease.”The drug, it turns out, modifies the activity of certain genes in an aged animal to resemble that of a younger rat. For example, the researchers found that the expression of a gene calledEAAT2, which has been linked to Alzheimer’s and is known to play a role in removing excess glutamate from nerve fibers, declines as the animals age. However, in rats treated with riluzole this gene’s activity was brought back to its youthful levels.New targets for treatments?In addition to its potential ability to allay memory loss and cognitive decline, riluzole is attractive as a potential treatment for Alzheimer’s. The drug is already being used to treat another neurological disease, amyotrophic lateral sclerosis, and is therefore considered relatively safe. In Pereira’s ongoing clinical trial, patients with Alzheimer’s disease have thus far been treated with either the drug or a placebo, and have been undergoing tests to help determine whether their brain functions have been improved.“We hope to use a medication to break the cycle of toxicity by which glutamate can damage the neurons that use it as a neurotransmitter, and our studies so far suggest that riluzole may be able to accomplish this,” Pereira says. “We found that in addition to recovering the expression of EAAT2, the drug restored genes critical for neural communication and plasticity, both of which decline with aging and even more significantly in Alzheimer’s disease.”The findings also help to lay the groundwork for further study of glutamate transporters as potential targets for treating both conditions.
Chinese tourists wearing masks use smartphones in the Ginza shopping district on January 24, 2020 in Tokyo, Japan. (Photo by Tomohiro Ohsumi/Getty Images)The Health Ministry in eSwatini (formerly Swaziland) has said it is monitoring its first suspected case of novel coronavirus.According to the South Africa Broadcasting Corporation(SABC), the case was identified on Friday.eSwatini’s director of Health Services Dr. Vusi Magagula said the woman recently entered eSwatini on 6 February after travelling from China to South Africa. Reports indicate that she is currently under quarantine in a hospital in Mbabane and blood samples have been taken for further analysis.“She presented with a fever and was at the hospital then the rapid response team took over and took up the case. She came through the Ngwenya Port of Entry on February 6 having arrived from the Republic of South Africa.“I don’t think she was presenting with any symptoms, we only picked her up on the 14th because she was already now in hospital, ill and had to be admitted to the isolation ward. So I guess when she passed through OR [Tambo airport] or even through Ngwenya border post she didn’t have the symptoms,” the SABC reported Dr Magagula as saying.On Friday, Egypt had confirmed its first case on coronavirus. This is the first case on the continent.Authorities have notified the World Health Organisation (WHO) and the patient, whose nationality was not given, was placed in an isolation ward at a hospital for treatment and monitoring.Related Suspected Ebola case reported in Kenya Liberia investigates new suspected case of Ebola Uganda’s health officials closely monitoring suspected case of Marburg
ST. CLOUD — Becoming a repeat champion in any sport is tough, and the St. Cloud Sluggers have their shot at it when they head to state this weekend.The Sluggers are an adapted softball team made up of kids from St. Cloud, Sauk Rapids and Sartell. They went 10-0 in the regular season, earning themselves the top seed heading into the state tournament.The last adapted softball team to repeat as state champs were Anoka-Hennepin in 2012. 720p HD 1080p HD About Connatix V56892 Auto (360p) Visit Advertiser website GO TO PAGE Skip 1/1 360p About Connatix V56892 Michael Bakken is the team’s head coach. He says they’re not too worried about offense this weekend.”We have people on our team that are 31 for 32 batting .969, another in the 890’s, and three in the 700’s. So our batting is good, we just have to play defense.”Bakken says they’re just trying to stay focused as they head into the tournament.”We’re just trying to stay focused, work on our fielding. We feel if we can field and not make many errors, we’ll be successful [this weekend].”The Sluggers scored double-digits in each of their games this season.Adapted softball switches the field for a gym, and the normal bat and ball for a wiffle ball and plastic bat. Their first test Friday night is against 4th ranked Mounds View/Irondale/Roseville. That’s at 7:00 p.m. at the Coon Rapids High School.
It was bound to come back at some point, but Manchester United are apparently interested in Paulo Dybala once more. The Argentine forward endured a rather disappointing season last year under Max Allegri, perhaps suffering the most out of everyone from Cristiano Ronaldo’s transfer to the Allianz Stadium.This led to him being seen as expendable by certain members of the media, with a profit possibly to be made by the Serie A champions.That’s why the rumours started flying, and with few clubs in the world capable of affording him, Manchester United were inevitably mentioned.There was a brief spell when it was quite a big story, only for it to disappear relatively quickly when everyone realised no movement was taking place.However, Gazzetta dello Sport bring it back, reporting the Red Devils have ‘made contact’ with Juventus.Embed from Getty ImagesThere’s even mention of a possible tête-à-tête taking place between the two sides, after which the possibility of a concrete offer will be evaluated.For now, Gazzetta state the ‘track is open’ for something to take place.There’s is one massive hurdle, however, and that’s the fact Paulo Dybala, at least for now, wants to stay at Juventus.That’s because Maurizio Sarri is now at the helm, and with the former Chelsea manager is thinking about using the Argentine as a false nine, there’s certainly more chance for him than there was last year.Furthermore, down Manchester United’s end, this all depends on whether Inter ever find the funds to sign Romelu Lukaku, which is by no means a guarantee.This seems like a lot of effort, and we all know how the Red Devils tend to fare when they have big hurdles to overcome during the transfer period.The answer, if you were wondering, is not very well.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksTrending TodayForge of Empires – Free Online GameIf You Like to Play, this City-Building Game is a Must Have.Forge of Empires – Free Online GameUndo聽多多 Hearmore.asia1969年前出生的香港居民現可免費試戴頂尖的歐洲助聽器聽多多 Hearmore.asiaUndoRaid: Shadow Legends | Free DownloadEven Non-Gamers Are Obsessed With This RPG Game (It’s Worth Installing!)Raid: Shadow Legends | Free DownloadUndoDating.comWhere do attractive singles meet in Tung Chung?Dating.comUndoKeto减肥1個簡單的妙招一夜「融化」腹部贅肉（今晚試試）Keto减肥UndoSmart Tech TrendOver 55? You Have to Try Those Revolutionary Glasses!Smart Tech TrendUndoSingles50Hong Kong: A 40+ Dating Site That Actually Works!Singles50UndoLoans | Search AdsNeed a loan? Search hereLoans | Search AdsUndoGeeks Reviews價格僅為HK$771 的便携自拍無人機正席捲香港Geeks ReviewsUndo
It is the duty of all South Africans to play their part in the fight against the abuse of women and children, Brand South Africa said as this year’s 16 Days of Activism for No Violence against Women and Children campaign got under way on Monday.“It is a basic human right to have a sense of safety and security,” Brand South Africa marketing and communications director Wendy Tlou said in a statement.“It is our duty as citizens of our country, young or old, men or women to play our part to build a non-violent and secure nation and make this a 365 day campaign in our country. “We call on you to speak out and encourage victims to seek help,” Tlou said. “We urge all men to support women and children, and play their part through active opposition of abuse.“As South Africa prepares to mark 20 years of democracy, there are many achievements and milestones that we can celebrate as a nation. We must begin to count as a success the way in which we treat women and children.”ABUSE ‘THREATENS OUR HARD-WON FREEDOM’‘It is the duty of all South Africans to play their part in the fight against the abuse of women and children’, says Brand South Africa at the launch of this year’s 16 Days of Activism for No Violence against Women and Children campaign (Image: GovernmentZA flickrstream)Women, Children and People with Disabilities Minister Lulu Xingwana echoed these sentiments during the launch of the 16 Days campaign in Mafikeng, North West province on Sunday.Xingwana said abuse threatened to erode many of the hard-earned gains of South Africa’s liberation struggle by condemning women and children to a life of fear and preventing them from being productive members of society.“We believe that the unacceptably high levels of gender-based violence require the collective efforts of all South Africans,” Xingwana said. “We remain convinced that empowering women will help us win the war against poverty, inequality, unemployment and abuse.”The 16 days of Activism for No Violence Against Women and Children is a worldwide campaign that raises awareness of the negative impact of violence on women and children and encourages people to act against abuse.The campaign runs worldwide from 25 November (International Day for the Elimination of Violence against Women) to 10 December (International Human Rights Day), with the government, business, civil society organisations, faith-based organisations and the media all participating in the awareness drive.MEASURES TO COMBAT GENDER VIOLENCESouth Africa is still home to high levels of violence against its women and children, despite a world-renowned Constitution and a legislative overhaul that safeguards women’s and children’s rights.In the last year, the government has established a National Council against Gender Based Violence as well as an inter-ministerial committee to look into the root causes of violence against women and children in the country.The reinstatement of sexual offences courts across the country over the next three years will also boost South Africa’s efforts to combat gender-based violence. The courts will feature specially trained officials, procedures and equipment to reduce the chance of secondary trauma for victims.And earlier this month, Xingwana said the government would be working to implement the National Action Plan for Children. The plan, approved by the Cabinet in May, is a comprehensive guide for all government departments and agencies for realising children’s rights.It takes into account the Constitution‚ international and regional treaties‚ South African legislation‚ the UN Millennium Development Goals and the National Development Plan.“It is crucial that we invest more time and effort and exercise more vigilance to ensure that all our children are safe and protected,” Xingwana said. “Twenty years into our democracy, our democratic government has done a lot for our children, but we acknowledge that a lot more still needs to be done.“We must continue to build a South Africa where our children feel safe and secure, and that responsibility falls on us as government and also on families, parents and communities. Our children need support from all of us.”Source: SAnews.gov.za
Why Tech Companies Need Simpler Terms of Servic… audrey watters Top Reasons to Go With Managed WordPress Hosting While a successful exit in the form of an acquisition may be the goal for many startups, the experiences of Backblaze, an online back-up and storage startup, demonstrate how time-consuming, challenging, and expensive the process can be, particularly when, as was the case with Backblaze, things fall apart. Backblaze was in the process of negotiating an acquisition with one of its partners and then with another business. Both deals fell through, and Backblaze CEO Gleb Budman penned a blog post chronicling the process to offer some insights and lessons learned for other companies entering the process.The Backblaze StoryAs Budman explains, when Backblaze received the first acquisition offer, the company had already discussed internally the three scenarios: The first: the offer would be too low, and Backblaze would not accept it. The second: the offer would be something the company would consider but wouldn’t be thrilled with. And the third and best scenario: an offer the company would accept.As the first offer fell into that first category – and after some negotiations into the second category – Backblaze approached some other companies to see if they were interested in making an offer as well. And sure enough, another company made an offer that sat better with the startup.Budman’s blog post explains in great detail (with the names of the prospective buyers obscured) the steps in the very lengthy negotiation and due diligence process. And “very lengthy” may be the key phrase here, as Budman notes buyer kept delaying the signing of a definitive agreement until on the Monday following the end of the exclusivity extension, the CEO called with an “I’m sooo sorry,” telling Backblaze it would need to restructure in order to finalize the deal. Backblaze balked, and said no. And with that, writes Budman, “We were roughly back to where we were six months earlier.”The Lessons LearnedOn one hand, that’s not a bad place to be. Backblaze is profitable and cash-flow profitable. The company has a service that customers love. But as Budman notes, so much time was spent on the acquisition negotiations that other aspects of building the business might have been ignored. Budman admits that there are far more “lessons learned” than one post can hold, but offers these five pointers:Build trust. “Ultimately, the difference between success and failure of a merger is whether the teams trust each other. Start early. Partner. Meet live. Talk to references. Do whatever it takes to make sure both sides trust each other. If either side doesn’t, no amount of legalese in a contract will help.”Getting acquired is expensiveFind great advisersKnow your wants and walkaways up frontRequire quick movementThe Backblaze post is worth reading in its entirety, particularly for first-time entrepreneurs or those with limited experiences with company acquisitions.Photo credits: Flickr user Sam A Web Developer’s New Best Friend is the AI Wai… Tags:#start#tips Related Posts 8 Best WordPress Hosting Solutions on the Market